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wottan

wottan

Vancouver, BC
July 2004

NOV 05, 2004 10:54 AM

Word is that Australian scientists have manufactured a mouse that only has half the standard amount of body fat despite an unrestricted diet.

Reportedly, this development is on the road towards a cure for the growing obesity problem that plagues much of the Westernized world.

The study was performed at the Garvan Institute in Sydney, Australia. Professor David James has stated that their 'hot mouse' has been made to burn energy much faster than normal.

"They're missing one gene and the absence of that one gene allows these mice to eat essentially the equivalent of an extra meal every day of their lives but despite that, they only have half the amount of body fat a normal mouse does," Prof James told AAP.

This missing gene has in it the plan for a protein that slows down fat to energy conversion. And despite these mice not having it, they enjoy the same life span and reproductive capabilities as normal mice.

A drug that could mirror this effect in humans would likely have the same effect, and such medication could be no further away than five years.

Vampirate

Vampirate

Durham, NC
October 2004

NOV 05, 2004 11:12 AM

A drug that could mirror this effect in humans would likely have the same effect, and such medication could be no further away than five years.


Of course, eating sensibly and exercising more is available right now, and has been for years.

Hank_Scorpio

Hank_Scorpio

Los Angeles, CA
October 2004

NOV 05, 2004 11:15 AM

You know, I developed a cure for obesity about three years ago; I stopped shoveling chili-cheese fries into my face and started going to the gym. Miraculously I lost 75 pounds.

navin

navin

Seattle, WA
September 2002

NOV 05, 2004 11:17 AM

am i the only one who thought this was a cure for Fat Mike?

MisterGraves

MisterGraves

Portland, OR
November 2003

NOV 05, 2004 11:21 AM

The western world...hell, almost everybody, loves convenience.
It doesn't matter that the world's agricultural yeild is dropping while the population continues to grow- just keep em skinny until it all collapses.

No price is too high for... beauty?

[Edited on Nov 05, 2004 by xer0yne]

Shal

Shal

Los Angeles, CA
October 2002

NOV 05, 2004 11:34 AM

navin said:
am i the only one who thought this was a cure for Fat Mike?




I actually mistyped it that way while I was editing the story.

Twice.

biggrin

[Edited on Nov 05, 2004 by Shalome]

legionnaire

legionnaire

Belgium
November 2003

NOV 05, 2004 12:18 PM

I hate to burst everyone's bubble, but this is not the first time this has happened. The leptin knockout mouse has the same phenotype, and I think there's a CCK model that does too. The Neuropeptide Y mouse and the Melanocortin-4 receptor mouse had similar phenotypes. There is as yet no drug available on the market taking advantage of these discoveries, and even direct leptin injections in morbidly obese patients had a very moderate effect on overall body weight. And pharmaceutical companies have been killing themselves trying to develop a drug that works on one of these system, all to no avail. Apparently metabolism is one of those areas where mice are pretty different from humans.

ClockworkJim

ClockworkJim

Levittown, NY
February 2004

NOV 05, 2004 12:23 PM

xer0yne said:
The western world...hell, almost everybody, loves convenience.
It doesn't matter that the world's agricultural yeild is dropping while the population continues to grow- just keep em skinny until it all collapses.

No price is too high for... beauty?

[Edited on Nov 05, 2004 by xer0yne]




So, what do we do then? Kill a third of the humans so that we have enough food?

walkswithbears

walkswithbears

United Kingdom
March 2003

NOV 05, 2004 12:24 PM

exercise?



(okay, it's a rat, but you get the idea. sheesh! tongue )

MrStitches

MrStitches

Brooklyn, NY
November 2003

NOV 05, 2004 12:24 PM

StackedUpXXII said:

A drug that could mirror this effect in humans would likely have the same effect, and such medication could be no further away than five years.


Of course, eating sensibly and exercising more is available right now, and has been for years.


What do I look like, a guy who's not lazy?

X

X

Lansing, MI
February 2003

NOV 05, 2004 01:17 PM

wouldent it simple be easier to enginear a pill that made people understand that eating junk food is bad for them.

stellartrane

stellartrane

Austin, TX
February 2003

NOV 05, 2004 01:25 PM

All you need is a good coke or speed habit. When you start caring more about the drug then food -- poof -- the pounds shed away. Just stay off the pot - it has the opposite effect.

SerialX

SerialX

Pensacola, FL
May 2003

NOV 05, 2004 01:42 PM

They are not fat!
*cries into an empty bucket of ice cream*

Bamf!

Helter

Helter

Chester, PA
OLD SKOOL

NOV 05, 2004 02:22 PM

I doubt that this will lead to anything immediately for the reasons that Legionnaire has mentioned. Still, in todays age there really is no reason for our body to convert all excess energy into fat in a completely unregulated way. The day will come when we have a way (aside from restricting intake, or increasing energy usage) to regulate our metabolic process.

Scopitone

Scopitone

Irvine, CA
OLD SKOOL

NOV 05, 2004 06:21 PM

StackedUpXXII said:

A drug that could mirror this effect in humans would likely have the same effect, and such medication could be no further away than five years.


Of course, eating sensibly and exercising more is available right now, and has been for years.



Ugh but like that takes time and like commitment and junk and like gross food that like isn’t sugar soaked and fried and like I don’t have time to exercise what with all the awesome TV on and like I have bad genes and BESIDES, have you seen the new Shrek Twinkies?! Look at these and try to resist them!


legionnaire said:
I hate to burst everyone's bubble, but this is not the first time this has happened. The leptin knockout mouse has the same phenotype, and I think there's a CCK model that does too. The Neuropeptide Y mouse and the Melanocortin-4 receptor mouse had similar phenotypes. There is as yet no drug available on the market taking advantage of these discoveries, and even direct leptin injections in morbidly obese patients had a very moderate effect on overall body weight. And pharmaceutical companies have been killing themselves trying to develop a drug that works on one of these system, all to no avail. Apparently metabolism is one of those areas where mice are pretty different from humans.




Must you always ruin dreams with empirical evidence and undeniable facts?

wottan

wottan

Vancouver, BC
July 2004

NOV 05, 2004 06:23 PM

Id like to see a pill that made people not simplify losing into just 'not eating so much'.

s5

s5

STAFF

San Francisco, CA

NOV 05, 2004 06:23 PM

the cure for obesity is eating right and physical activity.

FreakPirate

FreakPirate

Canada
November 2002

NOV 05, 2004 06:24 PM

navin said:
am i the only one who thought this was a cure for Fat Mike?



That's exactly what I read...

GoatsGoToHell

GoatsGoToHell

USA
OLD SKOOL

NOV 05, 2004 07:10 PM

Lolita

Lolita

SUICIDEGIRL

Oregon, USA

NOV 05, 2004 07:39 PM

I for one am ecstatic that there might finally, one day, be a world without fat mice.
godamn fat mice.

FermatsEnigma

FermatsEnigma

USA
August 2004

NOV 05, 2004 07:45 PM

We got diet food for cats now too? Next thing we're going to see atkins approve these mice. wink biggrin biggrin

FermatsEnigma

FermatsEnigma

USA
August 2004

NOV 05, 2004 07:47 PM

Scopitone said:
Must you always ruin dreams with empirical evidence and undeniable facts?


Those heavy involved in research and scientific endeavors have a tendency to be annoying that way. I do it all the time

Dr_Zoidberg

Dr_Zoidberg

Raymore, MO
June 2004

NOV 05, 2004 08:48 PM

s5 said:
the cure for obesity is eating right and physical activity.



Yes, but it doesn't help when the government approves high fattening things for consumption by ignorant people. Half of the problem is High Fructose Corn Syrup, a very high fattening base used in sodas.

legionnaire

legionnaire

Belgium
November 2003

NOV 05, 2004 11:15 PM

Scopitone said:
Must you always ruin dreams with empirical evidence and undeniable facts?



I live to please.

Legionnaire - ruining everyone's fun since 1977. wink

Phoebus

Phoebus

Italy
OLD SKOOL

NOV 06, 2004 12:10 AM

euphplayer said:

s5 said:
the cure for obesity is eating right and physical activity.



Yes, but it doesn't help when the government approves high fattening things for consumption by ignorant people. Half of the problem is High Fructose Corn Syrup, a very high fattening base used in sodas.



I believe that personal accountability is one of the most important things in the world.

Situational awareness is also helpful.
"Look, the things I'm eating--combined with my total lack of physical activity--are causing me to gain weight. Maybe I should change something in my routine!

Of course, this doesn't cover everyone. Lots of folks suffer from bad injuries that prevent them from being able to exercise effectively, and others suffer from genetic problems. I'm more talking about America's culture of inactivity and stupid eating more than anything else. frown

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