Francis Crick, Nobel laureate and the co-discoverer of the double-helical structure of DNA with James Watson and Rosalind Franklin, died today at the age of 88 from colon cancer.
The nature of DNA structure was, in 1953, the most pressing question in all of biology, and Watson, Crick and Franklin were in direct competition with the likes of Linus Pauling, who had already claimed a Nobel prize for his discovery of the alpha-helical motif in protein structure. Following his discovery Crick continued to work within the fields of molecular biology and biochemistry, making significant advances in the determination of protein strcture through x-ray crystallographic techniques.
Their groundbreaking scientific paper making public the three-dimensional structure of DNA has at its end of the most brilliant understatements in scientific history, "It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material," in effect answering two of biology's biggest questions at once; what is the structure of DNA and how does it replicate?
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