• news
  • SATURDAY NOVEMBER 3 2007 8:30 AM

The Six-Million Dollar Mouse



I hate mice. They are disgusting, filthy creatures. I'm sorry, but it's true. Sure, they may have those big, round, shiny black eyes and darling little scrabbly paws, but don't let them fool you -- when you least expect it, they will turn around and cannibalize their own cage-mate, wallow in its blood like some kind of miniature pure-white disciple of Satan, and then piss on your hand out of spite. If you have had a better experience with mice then I envy you, but if you ask me, it's just a matter of time. I'm not creeped out by much in the animal kingdom, but tiny rodents really know how to get me.

So yes, can someone please make mice more powerful and dynamic? Because, you know what, that would be great. I want a mouse that can not only charge me at twice the skittery speed of normal mice, but could chase me down for hours without stopping. Lord knows that's not a horror movie in the making once they decide to start working together. I want my greatest nightmares brought to life in vivid technicolor and tiny high-pitched squeaking. Oh, what's that you say, Case Western Reserve University? You're already working on it?

Case Western Reserve University researchers have bred a line of "mighty mice" (PEPCK-Cmus mice) that have the capability of running five to six kilometers at a speed of 20 meters per minute on a treadmill for up to six hours before stopping.



Hey, that sounds fantastic!

The mice, developed by Parvin Hakimi (the study's lead author) over the past five years, are actually the product of a bigger ongoing study concerning an enzyme called phosphoenolypyruvate carboxykinases (PEPCK-C) and its metabolic and physiological effects on skeletal muscle. To put it concisely, our little vermin friends' genetic code has been tweaked to overproduce the enzyme. They are, as a result, better able to process fatty acids for energy and in turn create much less lactic acid byproduct, leading to a speed and endurance the researchers have compared to "Lance Armstrong biking up the Pyrenees." It's not all they can do, either -- the little guys live twice as long as normal mice, and continue to healthily give birth years after their wild counterparts have grown too old and crotchety to even try.

Oh, and there's the whole "markedly more aggressive" thing, too.

It was evident from the beginning that these mice were very different from average mice. Hakimi commented, "From a very early age, the PEPCK-Cmus mice ran continuously in their cages." She said she could identify which mice were from this new line by simply watching their level of activity in their home cage. Animal behavior studies later demonstrated that the PEPCK-Cmus mice are seven times more active in their home cages than controls; in addition, the mice were also markedly more aggressive. "The enhanced level of activity noted in the PEPCK-Cmus mice extends well beyond two years of age; this is considered old-age for mice," the researchers said.



It's like the poor little guys are born with 'roid rage. Nevertheless, it's certainly fascinating when one considers what a little gene therapy could do for enhancing one's physical condition. When I say "fascinating," I of course mean a little scary and GATTACA-esque, but in the grand scheme of futuristic technology it's maybe a little lower on the terror totem than invisible tanks or spider-bat robots. Besides, there are currently only five hundred of the super mice bred and under study -- that's not enough for a hostile takeover, am I right?

Right?



_DictionaryGirl_ welcomes her new genetically-superior supermouse overlords.

 

Previous

PAGE: 

1 | 2

Next

Comments
Ferretbite

Ferretbite

Mexico
September 2006

NOV 03, 2007 08:36 AM

No, you're thinking of sewer rats & wild mice, the ones you keep as pets are actually fairly clean, and both are extremely intelligent. That being said, this would make a great "Ben Jr." or "Little Willard".

AmbientLight

AmbientLight

I'm lost
March 2005

NOV 03, 2007 08:54 AM

The Pentagon will probalbly incorporate them into their arsenal of roided super soldiers!

surreal

ohash

ohash

Columbus, OH
May 2007

NOV 03, 2007 09:08 AM

I really am not a fan of forcing genetic changes on anything. I think that evolution will make it happen if it's meant to.

That being said, I had a pet albino mouse when I was a kid. He was sweet and clean and to my knowledge never worshipped Satan.

Chriztian

Chriztian

Tallahassee, FL
September 2004

NOV 03, 2007 09:37 AM

as scary crazy as this is, the fact that they live twice as long is really interesting. Also I wonder if they are really more aggressive or if it is just that they are so much more active so they have more time where they get aggressive.

freshprncebelair

freshprncebelair

Ellicott City, MD
June 2004

NOV 03, 2007 10:03 AM

AmbientLight said:
The Pentagon will probalbly incorporate them into their arsenal of roided super soldiers!

surreal



They already have things that remove the bodies need to sleep.

You can have super soldiers with incredible endurance who don't need to sleep, with the only side effects of extreme aggression!

I'd volunteer to have this done to me. Who doesn't want to have amazing endurance and a longer life (and feel like im 20 at the age of 40)?

JunkyardAngel

JunkyardAngel

San Gabriel, CA
February 2006

NOV 03, 2007 10:15 AM

Mice might be a bit smelly, but they are really smart and funny.

Holdenwrites

Holdenwrites

Miami, FL
December 2004

NOV 03, 2007 10:35 AM

So many new overlords to welcome, so little time.

Moonrabbit

Moonrabbit

Vancouver, BC
February 2005

NOV 03, 2007 11:15 AM

Ferretbite said:
No, you're thinking of sewer rats & wild mice, the ones you keep as pets are actually fairly clean, and both are extremely intelligent. That being said, this would make a great "Ben Jr." or "Little Willard".



?!??!?!?!?!?!!??!?!?!??!??!?!???!?!??!?!?!?!?!?!?!?!??!??!!

Rats, yes. Mice no. Mice are horrible. I've had three adult mice, with 12 babies. Fuzzys too! Their eyes were almost ready to open.
The next day, no babies, just a couple bloody patches and random shaving caked organs.
I've seen a mother mouse eating the skin off the back end of a baby mouse while it crawled away, squeaking.

It might start with a cull due to over crowding or human scent on their babies. But once they can't eat just one, oh no. They go on to eat baby after baby without rhyme or reason. No matter how many they give birth to.

Cigarette

Cigarette

Cleveland, OH
April 2004

NOV 03, 2007 11:15 AM

ohash said:
I really am not a fan of forcing genetic changes on anything. I think that evolution will make it happen if it's meant to.



How do you think all the food you've ever eaten ever got to it's present state?

NoPantsDave

NoPantsDave

Cincinnati, OH
OLD SKOOL

NOV 03, 2007 11:22 AM

masterfrederick

masterfrederick

Beaverton, OR
November 2006

NOV 03, 2007 12:02 PM

Algernon approves.

/obscure?

legionnaire

legionnaire

Belgium
November 2003

NOV 03, 2007 12:23 PM

Just to clarify, the techniques used in the published studies were transgenic technology rather than gene therapy. Which is actually probably closer to what GATTACA was talking about (though not exactly the same) in that it would only really be possible to see something like this in humans if we all decided at some point in the future that we want to make our kids in vitro]/i] rather than the (significantly more fun) old fashioned way and that we're willing to fundamentally alter their genomes.

Gene therapy (the alteration of genes or the transcription of genes via the introduction of engineered viral vectors into an adult patient), which would be what is required for adults to incorporate these sorts of changes into them, is a much less proven technology, and is quite different from what the authors were talking about.

TheDarkHarlequin

TheDarkHarlequin

San Diego, CA
September 2006

NOV 03, 2007 12:51 PM

All I want to know is, if I feed super mice to my snake, will he be a super snake, cause that is significantly more interesting to me. Mice are cute, then they bite you, then you feed them to a real pet. biggrin

CancerSticker

CancerSticker

Austin, TX
February 2007

NOV 03, 2007 02:01 PM

I want to make a secret of nimh reference, but the literary card's already been played. frown

Cassiel

Cassiel

Aurora, CO
September 2004

NOV 03, 2007 02:18 PM

Flowers for Algernon?

Previous

PAGE: 

1 | 2

Next