A tale out of science fiction, health physicists have discovered a way to turn radioactive scorpion venom into a brain-cancer fighting treatment. The venom hails from the yellow Israeli scorpion. When combined with the radioactive substance iodine-131, the venom protein attaches itself onto the glioma cells, releasing radiation that kills the cell.
This experimental treatment would help patients with high-grade gliomas, a cancer causing death generally within the first year of diagnosis. Currently in phase 2 of human trials, the venom therapy is already showing hope for treatment, and longer survival rates.
As Jackson discovered, the TM-601 that does not bind to cells in the body is rapidly excreted in the urine. "Other tissues will receive some dose," he says, "but the vast majority of the dose is delivered to the cancer cells." To prevent the radioactive compound from being absorbed by the thyroid, which has a voracious appetite for iodine, the patients were given large amounts of non-radioactive iodine prior to the therapy to block the thyroid uptake of I-131.
I really do wonder how the researchers in question developed their thesis question. While I'm sure the actual thought process was based upon previous studies of venom properties, I much rather imagine them sitting in a dark room, talking about spiderman, possibly under the influence, and deciding it would be way cool to actually develop radioactive venom, you know, just to say I did that.
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