Mom, I'm Gay ... And It's Your Fault

Are you born gay or do you choose to be gay? This question has been floating around for a while.

UCLA research might be coming up with some clues.

A study has shown that the genetic makeup of the mother may determine whether or not her son will be gay.
The finding, detailed in the February issue of the journal Human Genetics, adds fuel to the decade-long debate about whether so-called "gay genes" might exist.

The researchers examined a phenomenon called "X chromosome inactivation" in 97 mothers of gay sons and 103 mothers whose sons were not gay.

[...]

Normally, X chromosome inactivation occurs at random: half of the cells in a woman's body will have one X chromosome inactivated, while the other half inactivates the other chromosome.

However, when the researchers in the current study examined cells from those women who had at least two gay sons, they found that 42 of them—or 23 percent—showed something different.

"Every single cell that we looked at in these women inactivated the same X chromosome," Bocklandt told LiveScience. "That's highly unusual."

In contrast, only 4 percent of mothers with no gay sons and 13 percent of those with just one gay son showed this type of extreme skewing.

Bocklandt thinks this suggest that a mother's X chromosomes partly influences whether her son is gay or not.

"We think that there are one or more genes on the X chromosome that have an effect on the sexual orientation of the sons of these mothers, as well as an effect on the cells we were looking at," Bocklandt said.

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