HIV

Do you know recently shown that phosphorothioate (PS) oligodeoxynucleotide (ODN) analogs, unlike their normal congeners, exhibit significant anti- HIV activity. The syntheses, melting temperatures (Tm), and nuclease susceptibilities of a series of phosphorothioate ODN analogs. These include all-PS duplexes, duplexes with one normal chain and the other chain either all-PS, or end-capped with several PS groups at both 3' and 5' ends. The DNase susceptibilities of the S-ODNs are much less than the normal phosphodiesters, but by contrast duplexes of poly-rA with S-dT40 are much more susceptible to RNase H digestion. The Tm's for AT base pairs of S-ODNs are significantly depressed relative to normals, while GC base pairs show much less Tm depression. The Tm's of S-dT oligomers with poly-rA are reduced relative to the duplexes with normal dA oligomers. These results have significance for the biological properties of these analogs as anti-message inhibitors of gene expression, and provide a rational basis for the S-dC/G sequences as potential effective anti-AIDS agents.
isnt that a trip.

nobody likes a smartass.

i'm sure it's very cool and impressive but i just got out of bed and can't be bothered to actually read all that with attention.

[Edited on Dec 07, 2005 by Snottlebocket]

I don't know if this will help get the girls to notice you. But I guess its worth a try, right?

sorry

PubMed Central (PMC) - C A Stein, C Subasinghe, K Shinozuka, and J S Cohen. April 1988;
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=336489

You should always cite your sources!

hell yeah at least someone is reading the samething as i am... no offense to anyone here but why does it seem that everyone here is jaded an has obtuse point of views. i mean I've only read a few posts an posted also only a few an all i seem to notice is negative childish Abominable treatment/feed back towards each other.

I'm not reading it, I just Googled it. Besides, it's almost older than some of SGs members.

And don't hate on my poor citing.

[Edited on Dec 07, 2005 by SupremePizzaMan]

My bad, i must not be to good at posting heh, i was bored an reading mindless blah an yeah the fact its from 1988 is the best part...

She speaks the truth. And what's that? She's not being callow or insensitive? Basically, you have five posts. You'll either fit right in or opt out of the boards and goto the groups.

Oh, and if the original post was supposed to be clever or funny, it sort of missed the mark. Maybe you should make a thread about dick size though. People love those threads.

It's just how some people function; it's their thing. I wouldn't worry about it. Conversely, starting a VERY non sequitur thread such as this one won't make you any friends.

You are such a treasure.

and now in english

[Edited on Dec 08, 2005 by tehpeanut]

Dude, are you taking the piss?

small words good.

So.. your penis isn't big enough for random cock shots I take it?

[Edited on Dec 08, 2005 by Someguysteve]

*blink*

Dude, I'm just writing a paper for my Teaching class right now about how I desperately want to be a Science teacher and would be all over that shit if only I didn't suck at science. Don't rub it in!

Maybe you and CommunistCanuck can go on a date.

i sure hope you understood what you just posted.

So did I from my genetics classes... and even then some of them aren't complete sentences. Was kind of a cool concept though.

Funny . . I was thinking that same thing, just the other day!

yea but this could be the best 1st post ever, if it is his 1st post